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The success of any structural biology project is dependent on achieving sufficient purity and concentration of the sample-of-interest. Samples for cryo-EM generally have lower requirements for purity and concentration compared to other structural methods, making it a highly attractive approach...

LARGE1 is a bifunctional glycosyltransferase that polymerizes matriglycan – a linear polysaccharide of alternating xylose and glucuronic acid – on dystroglycan. Mutations in LARGE1 which decrease matriglycan can cause muscular dystrophies that are sometimes accompanied by intellectual disability. Matriglycan acts...

The ankyrin-1 complex tethers the spectrin-actin cytoskeleton to the red blood cell (RBC) membrane, and acts as a metabolic hub, connecting membrane proteins that are involved in gas exchange, pH control, and regulation of cellular volume and deformability. Mutations in...

Cryo-electron microscopy (cryo-EM) has become the state-of-the-art technology to study the structures of helical assemblies like amyloid fibrils. The accumulation of these proteinaceous fibrils is associated with more than twenty degenerative diseases, one of which is known as ATTR amyloidosis...

Assembly-line polyketide synthases, such as the 6-deoxyerythronolide B synthase (DEBS), are large multienzyme systems prized for their ability to produce specific and complex polyketide products. By transferring protein-tethered substrates across multiple active sites in a defined linear sequence, these enzymes...

Transient receptor potential vanilloid member 1 (TRPV1) is a Ca2+-permeable cation channel that serves as the primary heat and capsaicin sensor in humans. In published work, we determined the structures of apo and capsaicin-bound fulllength rat TRPV1 reconstituted into lipid...