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The COVID-19 pandemic has claimed millions of lives and devastated the world economy. Garnering insights into the replication cycle of the causative agent, SARS-CoV-2, will aid the development of therapeutics. SARS-CoV-2 possesses one of the largest viral RNA genomes which...

Cryo-EM has revolutionized structural studies of G protein-coupled receptors over the past few years. More facile structure determination of active GPCRs has enabled the field to understand the molecular basis of receptor function at an unprecedented pace. I will discuss...

The outer membrane (OM) of Gram-negative bacteria is an asymmetric bilayer composed of LPS in the outer leaflet and phospholipids in the inner leaflet. It constitutes a robust barrier for the cell, often making bacteria resistant to antibiotics that are...

The adeno-associated virus (AAV) non-structural Rep proteins catalyze all the DNA transactions required for virus viability including, DNA replication, transcription regulation, genome packaging, and during a latent phase, site-specific integration. Rep proteins contain two multifunctional domains: An Origin Binding Domain...

Bridging between prebiotic life and acute problems in modern medicine: Ada E. Yonath, Professor, Weizmann Institute of Science, 2009 Nobel Prize Winner in Chemistry; In situ transmission electron microscopy of funtional properties and dynamic processes in materials: Rafal Dunin-Borkowski, Professor...

In bacteria, transcription and translation are coupled processes, in which movement of RNA polymerase (RNAP) synthesizing mRNA is coordinated with movement of the first ribosome translating mRNA. Coupling is modulated by the transcription factors NusG--which is thought to bridge RNAP...

Capturing motion by cryo-EM: Joachim Frank, Professor, Columbia, 2017 Nobel Prize winner in Chemistry; 'The Light Stuff': Imaging dynamic chemical processes with optically-coupled electron microscopy: Jennifer Dionne, Associate Professor, Stanford University.

The path towards affordable cryo-EM.   Given by Richard Henderson, Group Leader at MRC Laboratory  2017 Nobel Prize Winner in Chemistry; Microscopy in motion: understanding crystal growth through in situ electron microscopy. Frances M. Ross, Professor, MIT.

My group is interested in structure, function and dynamics of pentameric ligand-gated ion channels (pLGICs). The pLGICs are central players in mediating fast synaptic transmission in the neuronal- and neuromuscular junctions. My talk will focus on two members of the...