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CRISPR-associated transposition systems allow guide RNA-directed integration of a single DNA cargo in one orientation at a fixed distance from a programmable target sequence. In published work, we defined the mechanism explaining this process by characterizing the transposition regulator, TnsC...

CryoEM Evolution: Smarter, Faster, Cheaper: Bridget Carragher, Director at Simons Electron Microscopy Center, New York Structural Biology Center; In situ 4D-STEM: Andrew Minor, Professor, University of California, Berkeley, Department of Materials Science and Engineering

Bacterial pathogens are a threat to global health and have evolved elaborate strategies to infect their hosts, including the deployment of type IV secretion systems (T4SS). These membrane-embedded macromolecular machines transport proteins and DNA across multiple membranes to deliver cargo...

Structure-guided Coronavirus Vaccine Design: David Veesler, Associate Professor, University of Washington, Howard Hughes Medical Institute Investigator; Real Space Charge Density mapping of Single Defects by 4D STEM: Xiaoquing Pan, Professor, University of California, Irvine.

Chomosome Structure: Roger D. Kornberg, Professor, Stanford University, 2006 Nobel Laureate in Chemistry; Applications of Aberration-Corrected TEM for Alloy Design: Hamish L. Fraser, Professor, Ohio State University

The ability to fight a viral infection is essential for all organisms. Drosophila melanogaster utilizes RNA interference for the antiviral response. Here, the protein, Dicer-2, is used for small interfering RNA (siRNA) biogenesis and passing one strand of the siRNA...

CryoEM has revolutionized structural studies of membrane proteins over the last decade. Combined with membrane mimetics such as lipid nanodiscs, cryoEM allows for detergent-free structural determination of membrane proteins within a lipid bilayer more closely matching the native environment. I...

Sample preparation and data analysis are important steps in achieving high-resolution cryo-EM structures. In this talk, I will discuss the lessons and tips that I learned while studying three different membrane channels, including the proton-activated chloride channel (PAC), pannexin 1...