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Transient receptor potential vanilloid member 1 (TRPV1) is a Ca2+-permeable cation channel that serves as the primary heat and capsaicin sensor in humans. In published work, we determined the structures of apo and capsaicin-bound fulllength rat TRPV1 reconstituted into lipid...

CRISPR-associated transposition systems allow guide RNA-directed integration of a single DNA cargo in one orientation at a fixed distance from a programmable target sequence. In published work, we defined the mechanism explaining this process by characterizing the transposition regulator, TnsC...

CryoEM Evolution: Smarter, Faster, Cheaper: Bridget Carragher, Director at Simons Electron Microscopy Center, New York Structural Biology Center; In situ 4D-STEM: Andrew Minor, Professor, University of California, Berkeley, Department of Materials Science and Engineering

Bacterial pathogens are a threat to global health and have evolved elaborate strategies to infect their hosts, including the deployment of type IV secretion systems (T4SS). These membrane-embedded macromolecular machines transport proteins and DNA across multiple membranes to deliver cargo...

Structure-guided Coronavirus Vaccine Design: David Veesler, Associate Professor, University of Washington, Howard Hughes Medical Institute Investigator; Real Space Charge Density mapping of Single Defects by 4D STEM: Xiaoquing Pan, Professor, University of California, Irvine.

Chomosome Structure: Roger D. Kornberg, Professor, Stanford University, 2006 Nobel Laureate in Chemistry; Applications of Aberration-Corrected TEM for Alloy Design: Hamish L. Fraser, Professor, Ohio State University

The ability to fight a viral infection is essential for all organisms. Drosophila melanogaster utilizes RNA interference for the antiviral response. Here, the protein, Dicer-2, is used for small interfering RNA (siRNA) biogenesis and passing one strand of the siRNA...